Avian Sarcoma and Leukosis Virus Cytopathic Effect in the Absence of TVB Death Domain Signaling

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TVB receptors for cytopathic and noncytopathic subgroups of avian leukosis viruses are functional death receptors.

The identification of TVB(S3), a cellular receptor for the cytopathic subgroups B and D of avian leukosis virus (ALV-B and ALV-D), as a tumor necrosis factor receptor-related death receptor with a cytoplasmic death domain, provides a compelling argument that viral Env-receptor interactions are linked to cell death (4). However, other TVB proteins have been described that appear to have similar ...

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Cell killing by avian leukosis virus subgroup B (ALV-B) in cultures has been extensively studied, but the molecular basis of this process has not been established. Here we show that superinfection, which has been linked to cell killing by ALV-B, plays no crucial role in cell death induction. Instead, we show that signaling by the ALV-B receptor, TVB, a member of the tumor necrosis factor recept...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 2005

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.79.13.8243-8248.2005